Effect of subacute malathion application on oxidative stress biomarkers
نویسندگان
چکیده
Bu çalışmada malathionun oksidatif stres biyobelirteçleri ve karaciğer enzimleri üzerine etkileri ile kafeik asit fenetil esterin malathiona karşı koruyuculuğunun araştırılması amaçlandı. Çalışmada her grupta 10 adet hayvan olacak şekilde toplam 40 (200-240 g) erişkin erkek Spraque Dawley ırkı rat kullanıldı. kontrol (K) grubuna gavaj yoluyla 5 ml/kg mısır yağı, malathion (MAL) mg/kg malathion, malathion+kafeik ester (MAL+CAPE) intraperitoneal yolla CAPE (10 µmol/kg) 1 saat sonra (40 mg/kg), (CAPE) ise uygulandı. 15 günlük uygulama sonunda ratların ketamin/ksilazin anestezi altında intrakardiyak olarak kanları alındı hayvanlara servikal dislokasyon yöntemi Alınan kan örneklerinden elde edilen plazmada paraoksonaz (PON), aspartat aminotransferaz (AST), alanin (ALT) aktiviteleri yüksek dansiteli lipoprotein (HDL), malondialdehit (MDA) nitrik oksit (NO) düzeyleri analiz edildi. Analiz sonuçları değerlendirildiğinde, göre MAL MAL+CAPE gruplarında plazma PON aktivitesi HDL düzeylerinde azalma (P
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ژورنال
عنوان ژورنال: Journal of advances in vetbio science and techniques
سال: 2021
ISSN: ['2548-1150']
DOI: https://doi.org/10.31797/vetbio.917112